Sarcomas are malignancies of connective tissue, e.g., bone, cartilage, skeletal or smooth muscle, fibroblasts, fat cells, and blood vessels. They may occur at any age. Specific sarcomas are characteristic of different age groups, and given the number of different types of tissues involved, it is not surprising that there are at least 70 different histological types of sarcoma.
Around half of the sarcomas occur in the lower extremity, but any site in the body from the scalp to the toes may be affected.
Many different types of bone or soft tissue sarcomas can develop and affect the tissues.