- Anaemia
- Episodes of pain / Unexplained episodes of severe pain – such as bone pain, pain in the abdomen, chronic pain, which can result from bone and joint damage, ulcers, and so on
- Hands and feet swelling, known as dactylitis.
- Frequent infections that damage the spleen
- Delayed growth in infants & children and delayed puberty in teenagers
- Vision problems
- Fever
- Chest pain or chest discomfort
- Abdomen swelling
-
Pale skin or nail beds
-
Yellow tint to the skin – known as jaundice, or whites of the eyes – known as icterus
-
Signs of stroke – Includes seizures, weakness or numbness of arms/legs/both, sudden speech difficulties, and loss of consciousness. Give special attention in case children with any one of the symptoms.
- Acute chest syndrome – Chest pain, fever, and breathing difficulty due to lung infection or blocking blood vessels
- Hypertension signs – Shortness of breath and fatigue (Usually affects adults)
- Organ Damage – The lack of oxygen-rich blood can damage nerves and organs, including kidneys, liver, and spleen
- Blindness
- Leg ulcers – namely open sores on legs
- Gallstones due to high level of bilirubin
- Priapism – In terms of men, this disorder can have painful, long-lasting erections, which can lead to impotence over time
- Pregnancy Complications – the risk of miscarriage, premature birth, and having low birth weight babies due to high blood pressure/blood clots
- Painful crises, Aplastic crises, Iron overload, and Sickle nephropathy
