Diet – Diets high in red meat and salted or smoked foods increases the risk of small intestine cancer
Inherited syndromes – People with certain inherited conditions like
Familial adenomatous polyposis (FAP)
Peutz-Jeghers syndrome (PJS)
Hereditary nonpolyposis colon cancer (HNPCC)
Autoimmune Conditions – Autoimmune inflammatory bowel diseases like Crohn’s Disease and Celiac sprue increase the risk of small bowel cancers
Immunosuppression – People who are immunosuppressed (post-organ transplant or in conditions like HIV) are at a higher risk of developing Jejunal cancers.