- Sex – Duodenal tumors are slightly higher risk in men
- Age – Duodenal tumors tend to occur more often in older people. (average age at 60s and 70s)
- Smoking increases the risk of duodenal cancer
- Alcohol consumption increases the risk of duodenal cancer
- Diet – Diets high in red meat and salted or smoked foods increases the risk of duodenal cancer
- Inherited Syndromes- People with certain inherited conditions like
- Familial adenomatous polyposis (FAP)
- Peutz-Jeghers syndrome (PJS)
- Hereditary nonpolyposis colon cancer (HNPCC)
- Autoimmune Conditions – Autoimmune inflammatory bowel diseases like Crohn’s Disease, Celiac sprue increase the risk of small bowel cancers
- Immunosuppression – People who are immunosuppressed (post-organ transplant or in conditions like HIV) are at a higher risk of developing small bowel cancers like duodenal cancers.
