Factors that may increase your risk of cholangiocarcinoma include:
Primary Sclerosing Cholangitis leads to hardening and scarring of the bile ducts.
Chronic Liver Disease – Scarring of the liver due to chronic disease.
Congenital – People born with a choledochal cyst (Bile duct cyst present at birth), which causes dilated and irregular bile ducts.
Liver Fluke infection – Cholangiocarcinoma is associated with infection with a liver parasite that is contracted by consumption of raw or undercooked fish.
Age – It is more common in adults over 50 years of age.
Smoking – is associated with an increased risk of cholangiocarcinoma.